06 March 2008

Frog enables diabetes treatment

Diabetes is a major concern among most of the people around the world. Those who suffer from diabetes have to take insulin injection periodically since their body could not stimulate enough insulin. It has been discovered that a variety of frogs helps us in the treatment of diabetes. A compound secluded from the frog grows up to 27cm as a tadpole. After this stage it shrinks to reach the length of 4cm in adulthood and this stimulates insulin release. A synthetic version of the compound - pseudin-2 - could be used to produce new drugs. Around two million people in the UK have type 2 diabetes. This condition is more predominant among those whose suffer from obesity because the body does not produce enough insulin, or the insulin that is produced does not work properly. It means people cannot normalize their blood glucose levels accurately. Scientists have tested a synthetic version of pseudin-2, a compound which protects the paradoxical frog from infection. They found it stimulated the secretion of insulin in pancreatic cells. More importantly it does not engage any toxic effects on the cells. The synthetic version was better at stimulating insulin than the natural compound. This enables the compound to evolve as a potential drug for treating diabetes.



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